Electrophysiological mechanisms underlying sudden cardiac death



Publisher: Futura Pub. Co. in Mount Kisco, N.Y

Written in English
Cover of: Electrophysiological mechanisms underlying sudden cardiac death |
Published: Pages: 277 Downloads: 707
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Subjects:

  • Cardiac arrest.,
  • Heart conduction system.
  • Edition Notes

    Includes bibliographies and index.

    Statementedited by Burton E. Sobel, James V. Dingell, Michael B. Mock.
    ContributionsSobel, Burton E., Dingell, James V., Mock, Michael B.
    Classifications
    LC ClassificationsRC685.C173 E43 1982
    The Physical Object
    Paginationx, 277 p. :
    Number of Pages277
    ID Numbers
    Open LibraryOL3511280M
    ISBN 100879931795
    LC Control Number82071099
    OCLC/WorldCa13580069

  Brugada syndrome (BrS) is a rare inheritable cardiac disorder characterized by ST-segment elevation and a negative T-wave in leads V1–V3 of the ECG and an increased risk of sudden cardiac death from ventricular fibrillation (VF) 1, spite of intense research by means of clinical, experimental and genetic studies, the basis for these ECG abnormalities and the mechanism underlying . Magnitude of the Problem. Sudden cardiac death accounts for to deaths annually in the United States, depending on the definition used. 1 2 When restricted to death sudden in one study, and 88% of those were due to cardiac disease. 1 Sudden cardiac death is the most common and often the first. In the past century much has been learned about TWA and its potential role as a mechanism for arrhythmogenesis. TWA is a marker for sudden cardiac death and arises due to alternation of repolarization at the cellular level. In the heart, spatially discordant alternans provides a substrate for unidirectional block and reentry. This issue of Cardiac Electrophysiology Clinics edited by Drs. Mohammad Shenasa N. A. Mark Estes III and Gordon F. Tomaselli will cover Contemporary Challenges in Sudden Cardiac Death. Topics covered in this issue include Pathophysiology; Basic electrophysiological mechanism; Channelopathy and Myopathy as causes of sudden cardiac death; Public access to defibrillation; Sudden cardiac death .

The most frequent tachyarrhythmias are atrial and ventricular extrasystoles, atrial flutter and fibrillation, as well as ventricular tachycardia, that can be a cause of sudden death. The mechanisms underlying ventricular arrhythmias are conduction disturbances, prolongation of the QT interval, impaired coronary reserve and autonomic function. However, the cardiac electrophysiological substrate that underlies the BrS ECG and supports ventricular arrhythmias in the intact heart of BrS patients has not been elucidated. This article reports the results of panoramic electrophysiological mapping using noninvasive ECG imaging in 25 BrS patients. Diabetes is a common endocrine disorder with an ever increasing prevalence globally, placing significant burdens on our healthcare systems. It is associated with significant cardiovascular morbidities. One of the mechanisms by which it causes death is increasing the risk of cardiac arrhythmias. The aim of this article is to review the cardiac (ion channel abnormalities, electrophysiological. Book Description: Long QT syndrome is a heart rhythm disorder that can cause fast, chaotic heartbeats. In some cases, long QT syndrome can cause sudden death. Long QT syndrome may result from a genetic mutation or be caused by certain medications and medical conditions. The condition is treatable with medication, surgery, or an implantable device.

  Contemporary Challenges in Sudden Cardiac Death, An Issue of Cardiac Electrophysiology Clinics, E-Book (The Clinics: Internal Medicine) Kindle Edition by Mohammad Shenasa (Author), III N. A. Mark Estes (Author), Gordon F. Tomaselli (Author) & 0 more Format: Kindle EditionManufacturer: Elsevier. */ /*-->*/ Adenosine: Electrophysiological Phenomena and Mechanisms Weill Cornell cardiologists authored a comprehensive review focused on the unique properties of adenosine that make it a specific electrophysiological probe for identifying underlying supraventricular arrhythmogenic mechanisms and confirming ablative success. Alterations in the SCN5A gene encoding the cardiac sodium channel Nav have been linked to a number of arrhythmia syndromes and diseases including long-QT syndrome (LQTS), Brugada syndrome (BrS) and dilative cardiomyopathy (DCM), which may predispose to fatal arrhythmias and sudden death. We identified the heterozygous variant cA > G, p.(SerGly) in a year-old patient with . 3 hours ago  Sarcoidosis is an inflammatory granulomatous disease that can affect any organ. Systemic sarcoidosis is known to affect young adults, with a second peak in women >50 years of age, as demonstrated in Scandinavian and Japanese studies. 1 – 4 In the US, the lifetime risk of sarcoidosis is % for black people and % for white people. 1 The incidence of cardiac involvement has been.

Electrophysiological mechanisms underlying sudden cardiac death Download PDF EPUB FB2

The editors of this book undertook a formidable challenge in their attempt to present basic mechanisms responsible for the sudden death syndrome. In order to meet this challenge, they secured the assistance of many of the research scientists who work in this field to be contributing authors.

The 21 chapters they have contributed to this book vary considerably in length and : Marvin Dunn. Electrophysiological Mechanisms Underlying Sudden Cardiac Death. Peter T. Kuo, MD. This book presents a succinct compilation of the current information on sudden death obtained by investigators with a broad spectrum of scientific interests.

Thirty-five clinical investigators and basic scientists contributed 25 chapters Author: Peter T. Kuo. ELECTRO PHYSIOLOGICAL MECHANISMS UNDERLYING SUDDEN CARDIAC DEATH. Edited by Electrophysiological mechanisms underlying sudden cardiac death book E. SOBEL, }AMES V.

DINCELL, and MICHAEL B. MocJ. Mount Kisco, NY: Future Publishing,'JZT pp. t3.' The editors of this book undertook a tormidable challenge in their attempt to 11 present basic mechanisms responsible lOr the sudden death syndrome.

Genre/Form: Congress: Additional Physical Format: Online version: Electrophysiological mechanisms underlying sudden cardiac death.

Mount Kisco, N.Y.: Futura Pub. This article discusses the electrophysiological abnormalities that can be induced by hypoxia and hypercapnia, with a summary provided in Fig. Download: Download high-res image (KB) Download: Download full-size image; Fig. Electrophysiological mechanisms underlying ventricular arrhythmogenesis during exercise with : Sharen Lee, Guoliang Li, Tong Liu, Gary Tse.

Sudden Death in Heart Failure: Underlying Electrophysiological Mechanisms. Subramaniam C. Krishnan, Claudio D. Schuger & Sidney Goldstein Heart Failure Reviews volume 7, pages – ()Cite this article. Sudden cardiac death is a global health threat for which we have only partial answers.

With growing elucidation of the underlying pathophysiological mechanisms of sudden cardiac death, better patient identification and treatment options are being developed. These include risk stratification paradigms, ICD therapy, pharmacological options, ablative procedures, and other treatments.

This book. Rapid advancements in cardiac electrophysiology require today’s health care scientists and practitioners to stay up to date with new information both at the bench and at the fully revised 7th Edition of Cardiac Electrophysiology: From Cell to Bedside, by Drs.

Douglas Zipes, Jose Jalife, and William Stevenson, provides the comprehensive, multidisciplinary coverage you need. Purchase Electrophysiological Disorders of the Heart - 2nd Edition. Print Book & E-Book. ISBN3 Molecular and Cellular Basis of Cardiac Electrophysiology 4 Mechanisms of Re-entrant Arrhythmias 47 Sudden Cardiac Death 48 Syncope 49 Asymptomatic Electrocardiogram Abnormalities.

Features a mini-textbook of mechanisms, identification, analysis, and prognosis for most common arrhythmia types in the section on rhythms and arrhythmias. Provides management strategies for complex patient problems. Discusses hot topics such as genetics and cardiac arrhythmias, Brugada syndrome, and devices for the management of atrial.

One of the mechanisms by which it causes death is increasing the risk of cardiac arrhythmias. The aim of this article is to review the cardiac (ion channel abnormalities, electrophysiological and structural remodelling) and extracardiac factors (neural pathway remodelling) responsible for cardiac arrhythmogenesis in diabetes.

Mechanisms of Sudden Cardiac Death Circulation Research, Vol. No. 12 Cardiac arrhythmias in acute coronary syndromes: position paper from the joint EHRA, ACCA, and EAPCI task force.

Abnormal cardiac repolarization, including QT-interval prolongation and T wave abnormalities, are often observed in patients with diabetes, one of the leading chronic metabolic disorders associated with ventricular arrhythmias and sudden cardiac death.

Studies on cellular mechanisms of diabetes-induced repolarization abnormalities have. Abstract Sudden death among athletes is very rare (,–, annually) but it is still 2–4 times more frequent than in the age-matched control population and attracts significant media attention.

We propose a mechanism underlying sudden cardiac death in athletes that does not relate to myocardial ischemia but is based on. It is noteworthy that mechanisms underlying sudden cardiac death are difficult to determine and remain controversial, especially the proportion of sudden deaths attributable to major conduction defects or primary ventricular tachyarrhythmias.

As DM1 is a complex disease involving multiple systems, non-cardiac causes can also be involved. 6. Electrophysiological mechanisms underlying arrhythmogenesis in Brugada syndrome. To understand the electrophysiological basis of BrS, the ionic determinants of the normal cardiac action potential (AP) need to be discussed.

AP depolarization (phase 0) is mediated by voltage-gated Na + channels (I Na). Abstract. Sudden cardiac death accounts for overdeaths per year in the United States alone []. It most often occurs in the setting of diffuse coronary artery disease [9], and in about 25% of cases of sudden cardiac death, the event is the initial presentation of coronary disease [87].

Purchase Contemporary Challenges in Sudden Cardiac Death, An Issue of Cardiac Electrophysiology Clinics, Volume - 1st Edition. Print Book & E-Book. ISBNMutations involving cardiac ion channels result in abnormal action potential formation or propagation, leading to cardiac arrhythmias.

Despite the large impact on society of sudden cardiac death resulting from such arrhythmias, understanding of the underlying cellular mechanism is poor and clinical risk stratification and treatment consequently limited. Mechanisms underlying the protective effects of vagus nerve stimulation against ventricular fibrillation Abstract Sudden cardiac death as a result of lethal ventricular arrhythmias is a major cause of death in cardiac diseases such as heart failure and prior myocardial infarct.

It presents with an ECG expression of atypical right bundle-branch block (RBBB) pattern and ST-segment elevation (STE) in leads V1 through V3.

1,2 It is estimated that BrS causes ≈20% of sudden cardiac death in cardiac patients with structurally normal hearts. 1 Understanding its pathophysiological mechanisms is essential for improving risk.

This addition to the Clinical Approaches to Tachyarrhythmias (CATA) Series, written by the investigators who discovered and probed the Brugada Syndrome, discusses the history, etiology, pathology and clinical manifestations of sudden death.

From diagnosis, prognosis, to therapeutic approaches using the latest in cathater ablation techniques. Background— Cardiac hypertrophy is a major risk factor for arrhythmias and sudden cardiac death.

However, the underlying signaling mechanisms involved in the induction of arrhythmia and electrophysiological remodeling in cardiac hypertrophy are unclear. Sudden cardiac death (SCD) from any cause claims ,–, lives a year in the United States. The most common sequence of events leading to SCD appears to be the degeneration of ventricular tachycardia (VT; abnormal acceleration of ventricular rate) into ventricular fibrillation (VF), during which disorganized contractions of the ventricles fail to eject blood effectively, often.

This indicates that HIV itself can change the electrophysiological properties of the heart profoundly and cause cardiac arrhythmias and related sudden cardiac death. The current knowledge of the underlying mechanisms, as well as the emerging role of inflammation in these arrhythmias, are discussed here.

Rapid advancements in cardiac electrophysiology require today's health care scientists and practitioners to stay up to date with new information both at the bench and at the fully revised 7th Edition of Cardiac Electrophysiology: From Cell to Bedside, by Drs.

Douglas Zipes, Jose Jalife, and William Stevenson, provides the comprehensive, multidisciplinary coverage you need. Introduction. The sudden death of a young athlete is a rare event, but each case is a tragedy and receives much public attention.

The possibility that a young, healthy athlete may collapse and even die whilst physically active is difficult to comprehend; in particular because the most common cause of sudden death in young athletes is sudden cardiac death (SCD), that is, it is the heart (the. It has long been accepted that life-threatening cardiac arrhythmias (ventricular tachycardia, ventricular fibrillation, and sudden cardiac death) are more likely to occur in the morning after waking.

It is perhaps less well recognized that there is a circadian rhythm in cardiac pacemaking and other electrophysiological properties of the heart. Mechanisms underpinning cardiac electrical instability and sudden cardiac death (SCD) in rheumatoid arthritis (RA).

Ion channel modulation by cytokines, autonomic dysfunction, and cytokine-driven ventricular structural remodeling all contribute to electrical instability.

These may be partly mitigated by disease-modifying therapy. Sudden cardiac death (SCD) refers to death after an unexpected sudden cardiac arrest in a patient with or without known structural heart disease.

The incidence of SCD in the United States ranges from to events per year, 1, 2 depending on the criteria for SCD used for surveillance. Both cardiac and gastrointestinal arrhythmias can broadly be divided into non-reentrant and reentrant activity. The aim of this paper is to compare and contrast the mechanisms underlying arrhythmogenesis in both systems to provide insight into the pathogenesis of GI motility disorders and potential molecular targets for future therapy.A higher percentage or score denoted greater conduction stability or a normal rate adaptive mechanism.

Sudden cardiac death vs. non-sudden cardiac death group. Cardiac electrophysiological substrate underlying the ECG phenotype and electrogram abnormalities in Brugada syndrome patients.The indications for an invasive cardiac electrophysiology study can be broken down to two categories: diagnostic and risk stratification.

An EP study can accomplish the following goals (Homoud, ): • definitive diagnosis of an arrhythmia • establish an etiology for syncope • risk stratification for sudden cardiac death.